Resting State Alpha Electroencephalographic Rhythms Are Differently Related to Aging in Cognitively Unimpaired Seniors and Patients with Alzheimer’s Disease and Amnesic Mild Cognitive Impairment

Background: In relaxed adults, staying in quiet wakefulness at eyes closed is related to the so-called resting state electroencephalographic (rsEEG) rhythms, showing highest amplitude posterior areas alpha frequencies (8–13 Hz). Objective: Here we tested hypothesis that age may affect rsEEG (8–12 Hz) rhythms recorded normal elderly (Nold) seniors and patients with mild cognitive impairment due Alzheimer’s disease (ADMCI). Methods: Clinical datasets 63 ADMCI 60 Nold individuals (matched for demography, education, gender) were taken from an international archive. The investigated individual delta, theta, frequency bands, as well fixed beta (14–30 gamma (30–40 bands. Each group was stratified into three subgroups based on ranges (i.e., tertiles). Results: As compared younger subgroups, older one showed greater reductions major topographical effects regions. On contrary, relation displayed a lesser reduction those rhythms. Notably, pointed similar cerebrospinal fluid AD diagnostic biomarkers, gray white matter brain lesions revealed by neuroimaging, clinical neuropsychological scores. Conclusion: present results suggest represent deranging factor dominant seniors, while be more affected variants earlier versus later onset of AD.